antiangiogenic activity of thalidomide analogues substituted with nitrogen.

Use of a compound in the manufacture of a medicament for treating undesired angiogenesis in an animal or human, wherein the compound is selected from the following compounds: ** ** see formula or combinations thereof, wherein: R1 is independently -H, -OH, -CH3, -CH2OZ, -CH2OCOZ, -CH2 = CONZ2, or -CH2Z selected, in which Z is selected from H or - (CH 2) nH n is 1-10; R2 is independently selected from -NH-NH2, -NH-OH, -NH-OR3, -N = N-R3, -NHCOH3, -NHCOCH3, pyrazolidine, pyrazoline, tetrazole, imidazole, pyrazole, piperazine, or imidazoline; and R 3 is independently selected from pyrazolidine, pyrazoline, tetrazole, imidazole, pyrazole, piperazine, imidazoline or.