DNA 데이터베이스 좌위 확장 및 STR 분석 키트의 변경에 따른 검출값 상이(Discordance) 발생 비율 분석에 관한 연구

The forensic DNA database was managed according to the °ΠAct on the Protection and Use of DNA Identification Information°π enacted in July 2010, and the integrity and accuracy of the genetic information registered in this forensic DNA database was being emphasized. In this study, we analyzed the discordance (DC) ratio for each short tandem repeat (STR) locus in 21,160 samples received from January 2016 to October 2019 in order to contribute to improving integrity and accuracy of data. In addition, we also analyzed the change in DC ratio for each STR locus after the expansion of 20 core STR locus based on Combined DNA Index System (CODIS) of the FBI laboratory in January 2018. As a result, the DC ratio for each STR locus increased from 29 cases to 67 cases according to the expansion of the STR locus, and we selected the STR loci with a high DC ratio. Also, we were able to organize the three types of DC occurrence in this study. These results suggest that may help to minimize the STR data analysis error of crime scene evidence samples and to increase the reliability of the forensic DNA database.