Immunohistochemical study of KiSS1 and KiSS1R expression in human primary breast cancer: Association with breast cancer receptor status, proliferation markers and clinicopathological features.
2015
Recent studies have raised doubts about the
protective role of KiSS1/KiSS1R in breast malignancy
progression. However, the role of the KiSS1/KiSS1R
system in primary breast cancer remains largely
unknown. The aim of the present study was to
characterize the biology and invasiveness potential of
primary breast cancer through evaluation of
KiSS1/KiSS1R protein expression and cellular
localization with regard to lymph node metastasis status,
receptor status (ERs, PR and HER-2/neu), and
expression of aromatase, MMP-9, Ki-67 and Cyclin D1
in primary invasive breast cancer tissues.
We showed increased protein expression of both
KiSS1/KiSS1R and MMP-9 in the cancerous tissue
compared with noncancerous tissue adjacent to the
breast tumour. In the studied group of breast cancer
samples, we observed a positive correlation between
KiSS1 and MMP-9. We also showed a positive
correlation between KiSS1R and aromatase expression
in all studied breast cancers. We did not notice any
associations between the KiSS1/KiSS1R system and cell
cycle regulators. KiSS1/KiSS1R did not correlate either
with Cyclin D1 and Ki-67 or with receptor status.
However, we showed higher levels of KiSS1R
expression in ERα-negative cases than in ERα-positive
cases in patients with lymph node metastasis. Present
data do not confirm the protective role of KiSS1/KiSS1R
breast cancer progression, but our results do support the
hypothesis that the KiSS1/KiSS1R system is activated
even in primary breast cancer and sustained during
invasion to local lymph nodes.
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