[Synthesis of a chiral metal-organic framework using zinc oxide as zinc source for enantioselective adsorption of 2,2'-furoin racemate].

Chiral metal-organic frameworks (CMOFs),[Zn(L-mal)(H2O)2]n were prepared by using zinc oxide instead of the traditional metal inorganic salt as the zinc source, and their chiral separation performance was investigated. Equal amounts of ZnO and L-malic acid were dissolved in H2O, and[Zn(L-mal)(H2O)2]n were obtained by allowing the mixture to stand at room temperature for 24 h. Then, 100 mg[Zn(L-mal)(H2O)2]n as the adsorbent was added to 250 μL 1 g/L 2,2'-furoin racemate, and 4.5 mL isopropanol and 1 mL methanol were selected as the extraction solvent and elution solvent, respectively, for selective adsorption experiments. The final filtrate was analyzed by high performance liquid chromatography (HPLC). The results showed that[Zn(L-mal)(H2O)2]n exhibited better selective adsorption ability for R-2,2'-furoin with 20% enantiomeric excess (ee). This work provides a new method for the green preparation of CMOF and expands its application in the field of chiral separation.