Amide-Directed Ru-Catalyzed Hydrodemethoxylation of ortho-Methoxy-Benzamides and -Naphthamides: A DoM Reaction Counterpart
2018
A new ruthenium-catalyzed hydrodemethoxylation of ortho-methoxy-benzamides and -naphthamides involving amide-directed C–OMe bond activation and hydride reduction is disclosed. The reaction is general, proceeding under RuH2(CO)(PPh3)3 catalysis using either triethylsilane (Et3SiH) or diisobutylaluminum hydride (DIBAL-H) as the reductant. The corresponding C–N hydrodeamination reaction is also briefly reported.
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