Studies on the allergenicity of cow's milk. II. Effect of heat treatment on the allergenicity of milk and protein fractions from milk as tested in guinea pigs by parenteral sensitization and challenge.

As demonstrated by parenteral sensitization and challenge in anaphylaxis experiments with guinea pigs, a particular heat-denatured milk was shown to have lost the allergenicity of the alpha-lactalbumin fraction, partially lost that of the beta-lactoglobulin fraction, and retained the allergenicity of the alpha-casein fraction.