And a carrier for acid-sensitive polymer preparation and application of anticancer drugs delivered
2015
The present invention discloses an acid-sensitive polymer carrier and its preparation method and drug delivery applications for anticancer drugs, the carrier is a polymer which sodium polyglutamate carboxymethyl cysteine and connected to form a peptide bond . Polymer carrier of the invention for paclitaxel, doxorubicin, camptothecin delivery of anticancer drugs, prodrugs polymer bonded to it with these drugs in water can be formed by self-assemble to form nanoparticles, improved drug water-soluble and biocompatible, and release at the tumor accelerate acidic environment, to improve the efficacy and bioavailability of the drug.
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