QUANTITATIVE ANALYSIS OF DIFFERENT BRANDS OF DEXAMETHASONE TABLET MARKE TED IN MAIDUGURI METROPOLITAN COUNCIL

This experiment involves quantitative analysis of dexamethasone tablet marketed in Maiduguri Metropolitan Council usin g UV - Spectrophotometry and HPLC method of analysis in which the samples were dissolved in methanol and their absorbance were determined and compared to that of the standard. Percentage content for each of the samples was determined so as to note if it was within the acceptable range of 90 - 110% in the British Pharmacopoeia (BP) , for those that passed the test or , if it was below or above the range for samples that are substandard or highly concentrated. The amount of dexamethasone table t in each sample was d etermined (actual content) and compared with that of the stated amount (0.5mg). It was observed that out of the eight samples (AARON’S, KRIS, NKOYO, DEXAREL, LOKEL’S, ANISUN, CHAZMAX and DEXA) three of the samples (NKOYO, LOKEL’S and DEXA) met the BP requi rement for actual drug content range of 90 - 110% with percentage content of 98.1, 99.2 and 95.8% respectively, while the other five samples failed the test with values below and above the acceptable range. Keyword : Dexamethasone, Tablet, HPLC and UV - Spectro photometer