Receipt of systemic therapy in older versus younger patients (pts) with metastatic renal cell carcinoma (mRCC).

580Background: More than half of pts diagnosed with mRCC are age 65 or older. However, older pts are often under-accrued/under-represented in clinical trials, partly due to concerns about their ability to tolerate systemic therapy (Rx). Given this, efficacy data from the registration trials may not apply to older pts. Herein, we investigate whether older patients with mRCC are less likely to receive various lines of systemic Rx than their younger counterparts. Methods: Clinical data was obtained from a prospectively maintained mRCC registry at the Huntsman Cancer Institute, University of Utah. Older pts were defined as ≥65 yrs at initiation of first-line systemic Rx for mRCC. Univariate analyses of the lines of systemic Rx received were performed using the Chi-squared test. Comparison of ordered categorical variables was made with the Wilcoxon rank sum test. Results: 264 pts who received first-line Rx for mRCC between 2004-2018 were included, and 108 of them were older pts. For older pts, median age at fi...