Proton-pump inhibitors and risk of renal disease

Proton pump inhibitors (PPIs) are one group of drugs that inhibit gastric acid secretion by binding irreversibly to the gastric proton pump. This paper aimed to review the impact of PPIs on kidney function and structure by presenting the updated information in this regard. In this review, we summarize in electronic databases including Google Scholar, EMBASE, MEDLINE, Scopus and EBSCO during the period of 1980 to 2017 by using the following search terms; proton-pump inhibitors, kidney injury, renal diseases, adverse events of protonpump inhibitors, acute interstitial nephritis, renal injury and chronic kidney disease. The PPIs are known as one group of drugs that are well tolerated in healthy subjects and where serious harms are rare. The some reports reveal that long-term administration of PPIs is associated with adverse effects such as: increasing the incident risk of kidney injury, hyper-secretion of gastric acid after their withdrawal, bone fracture, decreased levels of blood magnesium, interaction with metabolism of antiplatelet agents, increased risk of enteric infections and community-acquired pneumonia. Proton-pump inhibitors and risk of renal disease (PDF Download Available). Available from: https://www.researchgate.net/publication/316284636_Proton-pump_inhibitors_and_risk_of_renal_disease [accessed Nov 08 2017].