Internal and external therapy with corticoids

: The toxicological, pharmacological, and clinical properties of corticoids are well understood. As their main actions are based on an uniform mechanism, it is impossible to separate beneficial effects from side effects. Therefore, any augmentation of the therapeutic activity is associated with an increased risk of side effects in systemic as well as in topical use. The topical application of highly potent corticoids also bears the risk of systemic side effects, especially those with prolonged activity. In addition, it has to be kept in mind that apart from the skin, the functions of various organs can be unfavorably affected when corticoids are systemically applied.