TRA2A promotes proliferation, migration, invasion and epithelial mesenchymal transition of glioma cells

Abstract TRA2A, Transformer2A proteins, plays important roles in paclitaxel resistance and progression of breast cancer. However, whether TRA2A was involved in the progression of glioma remains to be elucidated. In this study, our results demonstrated that the expression of TRA2A was higher in the glioma tissue than that of normal tissue. Overexpression of TRA2A in glioma SHG44 cell lines promoted the tumor cells proliferation, migration, invasion and epithelial mesenchymal transition (EMT), while, knockdown of TRA2A showed the opposite effect. Thus, our findings provide new insights into the role of TRA2A in the progression of glioma, and implicate the potential application of TRA2A in glioma therapy.