Multidimensional Nanoparticle Characterization through Ion Mobility-Mass Spectrometry

Multidimensional techniques that combine fully or partially orthogonal characterization methods in a single setup often provide a more comprehensive description of analytes. When applied to nanoparticles, they have the potential to reveal particle properties not accessible to more conventional 1D techniques. Herein, we apply recently developed 2D characterization techniques to nanoparticles using atmospheric-pressure ion mobility-mass spectrometry (IM-MS), and demonstrate the analytical capability of this approach using ultraporous mesostructured silica nanoparticles (UMNs). We show that IM-MS yields a 2D particle size-mass distribution function, which in turn can be used to calculate not only important 1D distributions, i.e. particle size distributions, but also nanoparticle structural property distributions not accessible by other methods, including size-dependent particle porosity and the specific pore volume distribution function. IM-MS measurement accuracy was confirmed by measurement of NIST-certifi...