Circadian Regulation of Metabolism in Health and Diseases

The importance of circadian rhythm has been established through its evolutionary conservation and its connection to many health conditions. Circadian deregulation has emerged as an important risk factor for metabolic disruption and related chronic diseases. Chronic diseases are on the rise worldwide, and emerging evidence points toward restoration of circadian rhythms as a propitious approach to preventing and improving prognosis of many chronic disorders. This review will outline the evidence supporting the importance of the circadian system in metabolism by debriefing the molecular basis for the interaction between circadian timing and metabolic health and behavioral, genetic, and human epidemiological studies indicating the health implications of chrono-disruption.