Factors predictive of maternal-fetal transmission of HIV-1 : preliminary analysis of Zidovudine given during pregnancy and/or delivery

Objective.-To assess maternal risk factors potentially influencing vertical transmission of human immunodeficiency virus, type 1 (HIV-1), including maternal CD4 cell count; presence of immune complex dissociated (ICD) p24 antigen; maternal zidovudine therapy during pregnancy and/or delivery; complications of pregnancy, such as preterm labor and birth; and obstetric events during labor and delivery, such as duration of labor, mode of delivery, chorioamnionitis, and maternal blood exposure. Design and Setting.-A nonrandomized prospective cohort study at a university medical center and two general hospital affiliates. Patients.-Sixty-three HIV-1-seropositive pregnant women and their 68 infants. Intervention.-Twenty-six mothers received zidovudine therapy during pregnancy and/or during labor and delivery