EXPERIMENTAL STUDY ON THE GENESIS OF RADIATION HAZARD. I. THE HISTOCHEMICAL CHANGES OF BLOOD CORPUSCLES BY IRRADIATION

On the hypothesis that a toxic substance is induced by irradiation, rabbit's blood cells were studied histochemically for the presence of a toxic substance. When the blood cells were damaged, the white blood cells were irradiated with successive doses of 300 r Freifeld toxic granules appeared, at a total dose of 1200 r (4 x 300 r) to the extent of 100%. Scharlach granules then appeared and a longer time was necessary to reach 100%. Therefore, the number of Scharlach granules was taken as an indication of the degree of damage. As the white blood cells decreased, the various toxic granules increased. After injection of P/sup 3//sup 2/, the Scharlach granules began to appear after 2 hr, but it took 48 hr to reach 100%. (Absts. Japan. Med., 1: No. 7,