Fourier interferometry/spectral imaging of response to metabolic challenges in perinuclear mitochondria of normal and malignant cells

Mitochondrial responses continue to be erratic but may exceed in intensity cytoplasmic ones. Malate responses recorded at nuclear sites (which seems to suggest the presence of a nuclear dehydrogenase pathway) are particularly enhanced in cells treated with mitochondriatoxic agents, e.g. anthralin and azelaic acid. Reported studies have implications: (1) in terms of cell metabolism, with eventual substrate dosimetry within cell compartments; (2) in terms of biomedical applications to cell diagnostics, prognostics, and therapeutics.