CARDIOMYOCYTE-SPECIFIC DELETION OF PLASMA MEMBRANE CALCIUM ATPASE1 (PMCA1CKO) EXACERBATES CARDIAC REMODELLING AFTER TRANSVERSE AORTIC CONSTRICTION LEADING TO DILATED CARDIOMYOPATHY IN MURINE MODEL

Heart Failure (HF) remains a major cause of morbidity and mortality worldwide. PMCA1, is an ATPase dependent calcium extrusion protein. Human genome wide association studies have shown it to be linked with hypertension, a common underlying cause for HF. Our group has previously generated novel PMCA1