Clinically and genetically atypical T-cell prolymphocytic leukemia underlines the relevance of a multidisciplinary diagnostic approach.

Prolymphocytic leukemia (PLL) is a rare clonal lymphoproliferative disorder of mature lymphocytes. The disease originates from B lymphocytes in approximately 80% of cases and from T lymphocytes in 20% of cases.[1][1] B-PLL and T-PLL are both characterized by an aggressive clinical course with