Prevalence of antiretroviral interactions with concomitant treatment, medicinal plants, drugs and alcohol

Objective: HIV infection has become a chronic condition. Older age and polypharmacy increases the risk of interactions. Our aim is to know the prevalence of antiretroviral associations with other drugs, medicinal plants, drugs and/or alcohol. Method: A cross-sectional, observational study was conducted on HIV-infected patients during three months. The detection and analysis of interactions was carried out based on the University of Liverpool database. The data analysis was performed using the statistical program SPSS 15. Results: 89 Patients were included in the study (72% males; mean of age was 42 years). We detected 293 associations with potential clinical significance and seven contraindications. The drugs that most likely caused interactions were darunavir (12.7%) and trimethoprim/sulfamethoxazole (5.5%). Conclusions: Although most of the recorded associations lacked of clinical significance, the detection of prevalent interactions may allow a better management of the therapy