Effect of ethanolic leaf extract of Ocimum sanctum onhaloperidol-induced catalepsy in albino mice
2007
Neuroleptic drugs used in the treatment of schizophrenia and other
affective disorders are known to produce extrapyramidal side effects.
Catalepsy induced by these drugs in animals has been used as a model
for the extrapyramidal side effects associated with antipsychotic
agents in human beings. In the present study, we have attempted to
evaluate the protective effect of the ethanolic leaf extractof Ocimum
sanctum (OS) on haloperidol (1.0 mg/kg, intraperitoneal
administration)-induced catalepsy in mice by employing the standard bar
test. Mice were allocated to seven groups, each group containing six
animals. The effects of the test drug OS (at 1.75, 4.25 and 8.5 mg/kg
doses) and the standard drugs, scopolamine (1.0 mg/kg) and ondansetron
(0.5 and 1.0 mg/kg doses) were assessed after single and repeat dose
administration for seven days, 30 minutes prior to the haloperidol. The
results suggest that OS has a protective effect against
haloperidol-induced catalepsy, which is comparable to the standard
drugs used for the same purpose. Our study indicates that OS could be
used to prevent drug-induced extrapyramidal side effects.
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