Effects of space food bar feeding on bone mass and metabolism in normal and unloaded rats

Abstract During spaceflights in the shuttle, rats are provided specific food bars. To determine whether this diet allows normal body and skeletal growth, we used four groups of rats fed either standard pellet food or space food bars during a 2-wk unloading experiment. We recorded food intake, body weight, tibial bone mass, and mineral content by ash analyses, cancellous bone volume, and cell activities by histomorphometry. We found that food intake was not different when comparing the two types of food, but that suspended animals had a lower food intake than normal loaded animals. Body weight and bone mass were found lower in suspended animals than in normal loaded animals. Finally, longitudinal growth rate, cancellous bone volume, and bone formation rate were lower in suspended animals, irrespective of the type of food. These results show that space food bar feeding did not affect normal body and skeletal growth, and that body and bone changes due to unloading were not significantly different in animals fed space food bars and standard food.