Islatravir Case Study for Enhanced Screening of Thermodynamically Stable Crystalline Anhydrate Phases in Pharmaceutical Process Development by Hot Melt Extrusion.

Daniel Skomski,Richard J. Varsolona,Yongchao Su,Jingtao Zhang,Ryan S. Teller,Seth P. Forster,Stephanie E. Barrett,Wei Xu

Islatravir Case Study for Enhanced Screening of Thermodynamically Stable Crystalline Anhydrate Phases in Pharmaceutical Process Development by Hot Melt Extrusion.

2020

Daniel Skomski
Richard J. Varsolona
Yongchao Su
Jingtao Zhang
Ryan S. Teller
Seth P. Forster
Stephanie E. Barrett
Wei Xu

The emergence of new active pharmaceutical ingredient (API) polymorphs in pharmaceutical development presents significant risks. Even with thorough polymorph screening, new pathways towards alterna...

Keywords:

Chemistry
Biochemistry
Chemical engineering
Crystal
hot melt
Extrusion
process development
Active ingredient

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