Physicochemical Approaches to the Mode of Action of General Anesthetics

The anesthetic potencies (ED50) of seven gaseous anesthetics have been determined in mice, using as a criterion abolition of the righting reflexes by the rolling response, with the following results: C2F4 17.7 ATA; SF4 5.4 ATA; Ar 15.2 ATA; Kr 4.5 ATA; Xe 0.95 ATA; N2O 1.50 ATA. These results are co