Effects of TNF-α-308G/A Polymorphism on the Risk of Diabetic Nephropathy and Diabetic Retinopathy: An Updated Meta-Analysis.
2020
Diabetic nephropathy (DN) and diabetic retinopathy (DR) are the major factors of
morbidity and mortality in the patients with diabetes mellitus (DM). Growing
studies have investigated the relationship between the
TNF-α-308G/A polymorphism and the susceptibility to DN and DR,
without achieving consensus. Thus, we conducted this meta-analysis to reach more
comprehensive conclusions for these issues. Eligible studies were retrieved
through electronic databases such as PubMed, Embase, Web of Science and China
National Knowledge Infrastructure. Summary of odds ratios (OR) and 95%
confidence intervals (CIs) were generated to evaluate the intensity of the
associations. Statistical analyses were performed by STATA 11.0 and RevMan 5.2.
There are fourteen eligible publications involving nineteen studies in this
meta-analysis. TNF-α-308G/A polymorphism was significantly
related to increasing risk of DN under recessive model (OR=1.37,
95% CI=1.03–1.83) and homozygous model (OR=1.54,
95% CI=1.15–2.06). Moreover, the similar results were
also obtained in Asian groups for DN (recessive: OR=1.69, 95%
CI=1.18–2.42; homozygous: OR=1.99, 95%
CI=1.38–2.86; respectively), and significant association was
also detected between TNF-α-308G/A and DN susceptibility in type
2 DM in recessive model (OR=1.39, 95%
CI=1.02–1.89). No significant association was observed between
TNF-α-308G/A and DR susceptibility in total analyses and
subgroup analyses by ethnicity and type of DM. TNF-α-308G/A
polymorphism may enhance the susceptibility to diabetic nephropathy, especially
in Asian population and in T2DM patients, but not diabetic retinopathy.
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