Diagnostic value of the modified Duke criteria in suspected infective endocarditis - the PRO-ENDOCARDITIS study.

Abstract Objectives To determine, whether relevant comorbidities stratify patient with and without IE and whether these may improve the diagnostic accuracy in addition to the modified Duke criteria. Methods and Results 261 consecutive patients (aged 60.1 ± 16.1 years, 62.8% male) with suspected IE were prospectively included in this single center observational trial. Modified Duke criteria and relevant comorbidities as well as clinical characteristics were assessed. 47 patients had IE, as confirmed by a clinical event committee. Patients with IE had a higher frequency of positive blood cultures (70.2% vs. 36.9%, p  Conclusion Modified Duke criteria provide excellent diagnostic value for the evaluation of suspected IE, mainly driven by transesophageal echocardiography.