Value of multiple models of diffusion-weighted imaging for improving the nodal staging of preoperatively node-negative rectal cancer.

To investigate the parameters of multiple diffusion-weighted imaging (DWI) models for improving nodal staging of preoperatively node-negative rectal cancer. A total of 74 rectal cancer patients without suspected metastatic lymph nodes on conventional MRI who underwent direct surgical resection between November 2018 and January 2020 were enrolled in this prospective study. DWI parameters of mono-exponential model (ADC), intravoxel incoherent motion (D, D* and f), stretched exponential model (DDC and α), and diffusion kurtosis imaging (MD and MK) within the whole tumor were measured to predict the nodal staging in rectal cancer patients. The D*, DDC, and MK values were significantly different in patients with pN0 and pN1-2 (all P < 0.001). The D*, DDC, and MK showed good diagnostic performance with the area under the receiver operating characteristic (AUC) of 0.788, 0.827 and 0.799. Multivariate analysis indicated D* (odds ratio, OR = 1.163, P = 0.003) and DDC (OR = 0.007, P = 0.019) as significant predictors of nodal staging. The combination of DDC and D* demonstrated superior diagnostic performance with the AUC, sensitivity, specificity and accuracy of 0.872, 0.800, 0.932 and 0.878, respectively. Multiple functional DWI parameters were potential to identify the rectal cancer patients with micro-nodal involvement for accurate treatment.