2-phenoxy-derivatives and 2-phenylsulfanyl-benzenesulfonamide CCR3 antagonistic activity for the treatment of asthma and other inflammatory and immunological disorders

2004 
A benzenesulfonamide derivative of formula (Ib), their tautomeric form, or a salt thereof: wherein: R1 ** ** formula represents fluoro, chloro or bromo; R2 represents fluoro, chloro or bromo; R3 represents cyano; R4 represents ** ** Formula wherein: R51 represents hydrogen, cyclopentyl, ethyl or methyl; and R52 represents methoxycarbonyl or C1-6alkyl substituted with methoxycarbonyl, methanesulfonylamino, indolyl, tetrazolyl, 1,2,3-triazolyl, 1,2,4-triazolyl, 1,2,5-triazolyl, 1,3,4-triazolyl , pyrrolidin-1-yl, 2-oxo-pyrrolidin-1-yl, 2,5-dioxo-pyrrolidin-1-yl, 2-oxo-piperidin yl-1-yl 2-oxo-piperidin-3-, 4 -oxo yl-piperidin-1-yl 2-oxo-piperidin-6-, 2,5-dioxo-piperidin yl-1-yl 2,6-dioxo-piperidin-1-, or 2,6-dioxo- piperidin-3-yl.
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