Local amyloidosis of the oral cavity in patientswith inflammatory periodontal disease and chronic heart failure

Background. Systemic and local amyloidosis can be evident in the oral cavity. Biopsy including oral mucosa biopsy is a standard of amyloidosis diagnosis. Oral mucosa species of the cheek, gingiva, tongue and lip were admitted for the histological investigation. Material and methods. Cheek and gingival biopsies of 32 patients with I-IV NYHA functional class of chronic heart failure (CHF) and suspected systemic amyloidosis were investigated histologically with heama toxylin-eosin and Congo red staining and immunohistochemical analysis to ƒ and ƒ antibodies (DAKO) and following investigation in the polar light. Results. Positive reaction was observed in 71,9 % cases, while systemic AL-amyloidosis (confi rmed by ƒ:ƒ disbalance) and genetic form of the amyloidosis with predominantly skin disease were diagnosed only in 3 cases (9,4 %). Dental investigation of the patients with CHF and congo-positive reaction determined high prevalence of the severe generalised periodontitis (37,5 %). Conclusion. Chronic generalized infl ammation of the periodontium may be the cause of the local amyloid deposition in the oral cavity.