LACK OF ADRENOCORTICAL HORMONE-LIKE EFFECTS OF CHLORMADINONE ACETATE IN GUINEA PIGS

Treatment with 0.01, 0.1 and 1.0% chlormadinone acetate (CMA) contained diets for 33 days to guinea pigs showed no signs of the depression in adrenal, thymus and leucocyte count and no elevation of serum cholesterol. By the treatment with 0.01 and 0.1% cortisol contained diets, however, the atrophy of adrenal and thymic cortex, hypercholesterolemia and the enlargement of liver were noted in this species. It was therefore concluded that CMA had no cortisone-like properties in guinea pigs even at the excessive doses.