Green Synthesis of N-Substituted Benzimidazoles: The Promising Methicillin Resistant Staphylococcus Aureus (MRSA) Inhibitors

Abstract The current investigation describes the synthesis of N-substituted phenyl acetamide benzimidazole based derivatives 3(a-f) and their systematic analysis against Methicillin Resistant Staphylococcus aureus (MRSA). These compounds were characterized by IR, 1H NMR, 13C NMR spectrometry, elemental analysis and Mass. The derivative 2-(1H-benzimidazol-1-yl)-N-(3-nitrophenyl) acetamide (3f) exhibited significant potent antibacterial activity (6 fold more potent as compared to the standard drug Sultamicillin) against the MRSA (ATCC 4330). The structural correlationship indicates that m-nitro phenyl at N-position of benzimidazole strongly favours the anti-MRSA activity compared to the p-nitro phenyl.