Study on the correlation between plasma concentration of B-type natriuretic peptide and prognosis of acute spontaneous intracerebral hemorrhage

Objective To investigate the relationship between plasma concentration of B type natriuretic peptide (BNP) and the severity and prognosis of patients with acute spontaneous intracerebral hemorrhage(ICH). Methods Review of 86 cases of patients with spontaneous intracerebral hemorrhage analysis in our hospital Department of Emergency/Surgical Intensive Care Unit (ED/SICU) were admitted within 6 hours of admission to collect blood samples, head CT, biochemical index, Glasgow Coma Scale (GCS) score and other clinical data, and detected within 6 hours after admission, the admission of third days and 7 days of plasma BNP concentration. The blood volume of cerebral hemorrhage was computed. The GCS was used to evaluate nerve function after admission. The survival of 28 days was observed. Results The concentration of BNP detected at 3 time points increased with the increase of the amount of bleeding in patients with acute cerebral hemorrhage and increased with the decrease of GCS score at admission (P 8 group was significantly higher than those of the control group (P 8 group (P 168 pg/ml for 6 hours, AUC was 0.814, the sensitivity was 75.0% and the specificity was 81.4%. Conclusions The concentration of BNP in patients with acute spontaneous intracerebral hemorrhage increased with the increase amount of bleeding and the decrease of GCS score at admission. The concentration of BNP in the 6 hours after admission was correlated with the severity and the prognosis of the disease, which can be used as the important reference indicators for evaluating severity and prognostic prediction. Key words: Natriuretic peptide, brain/ME; Cerebral hemorrhage/ME