Association between gene and schizophrenia

Objective To investigate the genetic association between the LOC345614 locus in 5q33 and schizophrenia. Methods The PCR-based restriction fragment length polymorphism(RFLP)technique was used to genotype single nucleotide polymorphism(SNP)among 91 Chinese Han Family trios consisting of fathers,mothers and affected offspring with schizophrenia. Results The distribution of genotype frequencies of rs154 110 was not deviated from the Hardy-Weinberg equilibrium;haplotype relative risk test(HRR)did not show a genetic association between rs154 110 and schizophrenia;transmission disequilibrium test(TDT)did not show significantly biased transmission from parents of affected offspring;however,rs154 110 was associated with delusion of sin,delusion of persecution and other delusion. Conclusion The rs154 110 itself is not associated with schizophrenia but it has significantly correlated with clinic symptoms(delusion of sin,delusion of persecution and other delusion).