Tunable Synthesis of 3‐Acyl‐2‐naphthols and 3‐Substituted Isocoumarins via Jones Reagent Promoted Cascade Reactions of 2‐(4‐Hydroxy‐but‐1‐ynyl)benzaldehydes.

Yan He,Xinying Zhang,Nana Shen,Xuesen Fan

Tunable Synthesis of 3‐Acyl‐2‐naphthols and 3‐Substituted Isocoumarins via Jones Reagent Promoted Cascade Reactions of 2‐(4‐Hydroxy‐but‐1‐ynyl)benzaldehydes.

2014

Yan He
Xinying Zhang
Nana Shen
Xuesen Fan

It is found that treatment of benzaldehydes of type (I) and (V) with 0.7 equivalents of Jones oxidant followed by column chromatography on silica gel pre-eluted with NEt3 results in efficient formation of 3-acyl-2-naphthols.

Keywords:

Silica gel
Column chromatography
Cascade
Isocoumarins
Chemistry
Reagent
Organic chemistry

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