Gallotannin is a DNA damaging compound that induces senescence independently of p53 and p21 in human colon cancer cells

The plant secondary metabolite gallotannin (GT) is the simplest hydrolyzable tannin shown to have anti-carcinogenicproperties in several cell lines and to inhibit tumor development in different animal models. Here, we determined if GTinduces senescence and DNA damage and investigated the involvement of p53 and p21 in this response. Using HCT116human colon cancer cells wildtype for p53