Diagnostic performance of a sonographic Volume and Solid Vascular Tissue Score (VSVTS) for preoperative risk assessment of pediatric and adolescent adnexal masses.

Abstract Study objective To evaluate the diagnostic performance of a Volume and Solid Vascular Tissue Score (VSVTS) for preoperative risk assessment of pediatric and adolescent adnexal masses. Design A retrospective cohort study comprised of all females who presented with an adnexal mass that was managed surgically between April 2011 and March 2016. Setting The Hospital for Sick Children (Toronto, Ontario, Canada). Participants Females aged 1 – 18 years old who presented to a large tertiary pediatric hospital with an adnexal mass that was managed surgically. Main Outcome Measures Main outcome measures included diagnostic performance of the VSVTS for malignancy via sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (LR+), negative likelihood ratio (LR-) and receiver operatic characteristic area under the curve (AUC) analysis. Results 179 masses in 169 subjects were included. The malignancy rate was 10.6%. AUC for the VSTVS was 0.919. A VSTVS cut-off value of 4 achieves a sensitivity of 79% [95% CI 0.54 – 0.93], specificity of 88% [95% CI 0.82 – 0.93], PPV of 0.44 [95% CI 0.33-0.56], NPV of 0.97 [95% CI 0.94 – 0.99], LR+ of 6.77 [95% CI 4.18 – 10.97], and LR- of 0.24 [95% CI 0.10 – 0.57]. Conclusions A sonographic scoring system based on the volume and presence of solid vascular tissue improves PPV for pre-operative risk stratification of adnexal masses in the pediatric and adolescent population compared to existing ultrasound-only approaches. Further prospective research is needed to determine how best to incorporate components of such scoring systems into clinical management algorithms.