Antimutagenic activity of plumbagin in Ames Salmonella typhimurium test.
1992
This paper reports the antimutagenic activity of plumbagin (5-hydroxy-2-methyl-1,4-naphtoquinone) against certain known cheical mutagens in a standrd mutagenicity test system of Ames using S. typhimurium strains. Plumbagin by itself did not show any mutagenic effect, whereas it reduced significantly the mutagenic effect of 4-nitrophenylene diammine, phenyl hydrazine and sodium azide in test strains of S. typhyimurium, suggesting that plumbagin possessed antimutagenic activity
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