Aristolochic acid nephropathy: a global public health issue that still needs attention

Aristolochic acid nephropathy (AAN) is not only a common chronic renal interstitial disease in China, but also one of the pathogenic factors of Balkan endemic nephropathy. Due to the disease involvement of a large geographic area and population, and the lack of effective treatment, a significant proportion of AAN patients progress to end-stage renal disease (ESRD), which has become a global public health problem. Strengthening the publicity, education, supervision, and management of AA nephrotoxicity, further exploring the pathogenesis of AAN, and seeking effective intervention targets have important scientific and practical significance for not only correct understanding and use of Chinese medicine, but also reducing the prevalence of ESRD. Key words: Aristolochic acid (AA); Aristolochic acid nephropathy (AAN); Chinese herbs