Bäckerhefe Saccharomyces cerevisiae als universelle chemische Mikrofabrik

One of the applications of the emerging synthetic biology field is the enzymatic production of chemicals, either by individual enzymes or by cascades of whole metabolic pathways. Here, the discovery of novel metabolites from baker’s yeast transformed with yeast artificial chromosomes is described. One particular class of compounds found repeatedly are structurally diverse novel polyketides obtained by expression of mixes of PKSIII (polyketide synthase type III).