Association of the polymorphism for the vitamin D receptor gene and the susceptibility to pulmonary tuberculosis in population of Chinese Uighurs.

To investigate the association of the polymorphism for the vitamin D receptor gene and the susceptibility to pulmonary tuberculosis in this population,the Fok1 and Taq1 genes for the vitamin D receptor(VDR) were typed in 224 patients with active pulmonary tuberculosis(TB) in Chinese Ughurs and 225 healthy individuals of the same population who had been contacted with TB.and the relationship of these kinds of polymorphism with the incidence of TB was studied by means of the statistical method,such as χ2 test.It was found that the percentages of the 3 genotypes of FF,Ff and ff in patients with active pulmonary TB were 36.2%(81/224),56.7%(127/224) and 7.1%(16/224) respectively;while those in the healthy controls were 40.4%(91/225),53.3%(120/225) and 6,2%(14/225) respectively.No significant difference in the distribution of the FF genotype of VDR could be detected between patients and healthy controls(χ2=0.872,P0.05).The FF,Ff and ff genotypes in patients were 68.6%(154/224),29.4%(66/224) and 1.8%(4/224);while those in healthy controls were 75.6%(170/225),22.2%(50/225) and 2.2%(5/225) respectively,also no significance between these two groups(χ2=2.588,P0.05).It is evident that no significant association exists in the polymorphism of the Fok1 and Taq1 loci of the vitamin D receptor gene and the susceptibility to pulmonary tuberculosis in population of Chinese Uighurs.