Antibodies and fragments thereof that bind to IL-1beta the

Antibody that binds to IL-1beta or fragment thereof that binds to IL-1beta, wherein said antibody or fragment binds to human IL-1beta with a constant disociaci HERE TO less than 1pM, said antibody or fragment thereof selected from the group consisting of: * a variable region light chain comprising the amino acid sequence of SEQ ID NO: 9 or SEQ ID NO: 9 with one or more conservative amino acid substitutions and a variable heavy chain region comprising the amino acid sequence of SEQ ID NO: 8 or SEQ ID NO: 8 with one or more conservative amino acid substitutions; * A variable region light chain comprising the amino acid sequence of SEQ ID NO: 10 or SEQ ID NO: 10 with one or more conservative amino acid substitutions and a variable heavy chain region comprising the amino acid sequence of SEQ ID NO: 14 or SEQ ID NO: 14 with one or more conservative amino acid substitutions; * A variable region light chain comprising the amino acid sequence of SEQ ID NO: 11 or SEQ ID NO: 11 with one or more conservative amino acid substitutions and a variable heavy chain region comprising the amino acid sequence of SEQ ID NO: 15 or SEQ ID NO: 15 with one or more conservative amino acid substitutions; * A variable region light chain comprising the amino acid sequence of SEQ ID NO: 10 or SEQ ID NO: 10 with one or more conservative amino acid substitutions and a variable heavy chain region comprising the amino acid sequence of SEQ ID NO: 25 or SEQ ID NO: 25 with one or more conservative amino acid substitutions; * A variable region light chain comprising the amino acid sequence of SEQ ID NO: 11 or SEQ ID NO: 11 with one or more conservative amino acid substitutions and a variable heavy chain region comprising the amino acid sequence of SEQ ID NO: 26 or SEQ ID NO: 26 with one or more conservative amino acid substitutions.