5,7-Dimethoxy-3-(2′-hydroxybenzyl)-4-chromanone inhibits α-glucosidase in vitro and alleviates postprandial hyperglycemia in diabetic mice
2019
Abstract This study was designed to investigate the inhibitory activities of 5,7-dimethoxy-3-(2′hydro-xybenzyl)-4-chromanone (5,7-D chromanone) isolated from Portulaca oleracea L. on carbohydrate digesting enzymes and its ability to improve postprandial hyperglycemia in streptozotocin-induced diabetic mice. 5,7-D chromanone strongly inhibited α-glucosidase and α-amylase (half-maximal inhibitory concentration, IC50; 15.03 ± 2.59 μM and 12.39 ± 2.16 μM, respectively). The inhibitions were more effective than acarbose, which was the positive control. The increase in blood glucose level after ingesting starch was more significantly alleviated in the 5,7-D chromanone ingested group than in the control group of diabetic mice. In the control group, blood glucose levels were 24.64 ± 1.73, 27.22 ± 1.58, and 26.37 ± 1.41 mM, and in the 5,7-D chromanone ingested group were 23.87 ± 1.10, 23.38 ± 1.32, and 21.42 ± 1.36 mM at 30, 60, and 120 min, respectively. In addition, the area under the curve of blood glucose significantly declined with 5,7-D chromanone ingestion in diabetic mice. The results indicate that 5,7-D chromanone can help lower postprandial hyperglycemia by inhibiting carbohydrate digesting enzymes.
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