Preterm labour: Novel treatments

Prematurity is a major cause of perinatal death and childhood disability. The risks are increased at early gestational ages so that a delay in delivery by preventing preterm labour or inhibiting uterine contractions can improve outcome for the newborn. Here, we review the mechanism of action and clinical evidence for the renewed enthusiasm for prevention of preterm delivery in high-risk women by administration of progesterone. At present, there is also controversy regarding the optimal management of threatened preterm labour, so we outline the rationale for treatment and clinical evidence for administration of an oxytocin antagonist in acute situations.