Influence of echinocandin administration on hemodynamic parameters in medical intensive care unit patients: a single center prospective study

Purpose Fungal infections present a constant risk to critically ill and immunocompromised patients. Therefore, treatment guidelines recommend echinocandins as first-line antifungals in critically ill patients to improve patient outcomes. Echinocandins are usually well tolerated; nevertheless, rare adverse events can occur. There are reports of temporary deterioration of hemodynamic parameters during loading doses, especially in critically ill patients. The objective of this study is to analyze the hemodynamic changes during adminstration of the echinocandin antifungals, caspofungin and anidulafungin, in medical intensive care unit patients.