Immunoendocrine homeostasis in mice after local irradiation of immune and endocrine system organs

: Immunoendocrinological studies were carried out in mice during a year after local X-ray irradiation of thymus, hypothalamus-hypophysis, gonads, spleen and thigh muscles. Irradiation of the organs caused the stress regardless of the dose and localisation. No stable immunoendocrinological changes was observed in exposed spleen and thigh muscles. Post-irradiation disfunction of the central and peripheral endocrine gland (hypothalamus-hypophysis, gonads, thymus) induced alterations in function of other endocrine glands and depressive state of the endocrine system. Functional deviations in immune and endocrine systems has a phase character with some dose dependence. The effect of combined irradiation of thymus and hypothalamus-hypophysis is similar to those under separate irradiation.