Antitumor Immunity (Mechanism, Immunoediting, Immunosurveillance)

The existence of an antitumor immunity, which involves multiple effectors belonging both to adaptative and innate immunity, has been clearly established. The inhi- bition of this immunosurveillance is a prerequisite to a tumor development and will follow a Darwinian selection of mini- mal immunogenic tumor clones which will succeed in esca- ping our immune system. The restoration of this antitumor immunity is a key therapeutic challenge as it will not only provide antitumor activity but also hope for a specific targe- ting of tumors and moreover allow a sustained efficacy by assuring an immune memory.