Characterization of a cryptic IGH/CCND1 rearrangement in a case of mantle cell lymphoma with negative CCND1 FISH studies

Jess F. Peterson,Linda B. Baughn,Rhett P. Ketterling,Beth A. Pitel,Stephanie A. Smoley,George Vasmatzis,James B. Smadbeck,Patricia T. Greipp,Abhishek A. Mangaonkar,Carrie A. Thompson,Sameer A. Parikh,Dong Chen,David S. Viswanatha

Characterization of a cryptic IGH/CCND1 rearrangement in a case of mantle cell lymphoma with negative CCND1 FISH studies

2019

Jess F. Peterson
Linda B. Baughn
Rhett P. Ketterling
Beth A. Pitel
Stephanie A. Smoley
George Vasmatzis
James B. Smadbeck
Patricia T. Greipp
Abhishek A. Mangaonkar
Carrie A. Thompson
Sameer A. Parikh
Dong Chen
David S. Viswanatha

Key Points This article characterizes a cryptic IGH/CCND1 rearrangement in MCL by NGS. Mate-pair sequencing can help in accurately diagnosing MCL in cases of cyclin-D1–positive B-cell lymphoma with negative CCND1 FISH studies.

Keywords:

Cyclin D1
Molecular biology
Biology
Mantle cell lymphoma
Lymphoma
Chronic lymphocytic leukemia
Cell cycle
Cyclin D
Immunoglobulin light chain
Hairy cell leukemia

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