Click Chelators – The Behavior of Platinum and Palladium Complexes in the Presence of Guanosine and DNA

Triazole chelators, synthesized by click chemistry, are convenient ligands for palladium(II) and platinum(II). Conformational changes induced by the complexation of these Pd II and Pt II complexes with guanosine are similar to those of cisplatin. In addition, these complexes behave like cisplatin with regard to the relaxation of supercoiled plasmid DNA.