Xylocydine（5-氨甲酰基-4-氨基-6-溴-7-（β-L-呋喃木糖）吡咯[2，3-d]嘧啶）的合成

Xylocydine (4-amino-5-carboxamide-6-bromo-7-(β-L-xylofuranosyl) pyrrolo [2,3-d] pyrimidine), a novel inhibitor of CDK (cyclin-dependent kinases) with high anticancer activity, was synthesized. Firstly, two intermediates, 4-amino-6-bromo-5-cyanopyrrolo [2,3-d] pyrimidine (Ⅰ) and 1-O-acetyl-2,3,5-tri-O-benzoyl-L-xylofuranose (Ⅱ), were prepared using tetracyanoethylene and L-xylose as starting materials. Then xylocydine was synthesized via three-step reaction including glycosylation of compound Ⅰ with Ⅱ, subsequent hydrolysis of benzoyl group and oxidation of cyano group. The structure of xylocydine was indentified by 1H NMR, 13C NMR and IR spectrum.