Topsentiasterol sulfates, antimicrobial sterol sulfates possessing novel side chains, from a marine sponge, Topsentia sp.

Abstract Five novel antimicrobial steroid sulfates, topsentiasterol sulfates A-E ( 1-5 ) have been isolated from a marine sponge, Topsentia sp. Their structures were elucidated to be 2,3,4,6-tetrahydroxy-14-methyl Δ 9(11) sterol-2,3, 6-trisulfates with unusual side chains. Topsentiasterol sulfates A-D have side chains terminating in furan-butenolide type functions. Topsentiasterol sulfate E is a C31 compound.